Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study.

Cohen S, Roy J, Lachance S, Delisle JS, Marinier A, Busque L, Roy DC, Barabé F, Ahmad I, Bambace N, Bernard L, Kiss T, Bouchard P, Caudrelier P, Landais S, Larochelle F, Chagraoui J, Lehnertz B, Corneau S, Tomellini E, van Kampen JJA, Cornelissen JJ, Dumont-Lagacé M, Tanguay M, Li Q, Lemieux S, Zandstra PW, Sauvageau G.
Lancet Haematol (2019).

s a homeostatic inflammatory-detoxification response supporting human HSC self-renewal.

Chagraoui J, Lehnertz B, Girard S, Spinella JF, Fares I, Tomellini E, Mayotte N, Corneau S, MacRae T, Simon L, Sauvageau G.
UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal.
PLoS One (2019), 14(11).

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.

Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G. Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.                                                                                                                                                         Cancer Cell (2019), 36(1):84-99.

Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition.

Moison C, Lavallée VP, Thiollier C, Lehnertz B, Boivin I, Mayotte N, Gareau Y, Fréchette M, Blouin-Chagnon V, Corneau S, Lavallée S, Lemieux S, Marinier A, Hébert J, Sauvageau G.
Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition.
Blood Adv. (2019), 3(4):552-563.

Genetic characterization of ABT-199 sensitivity in human AML.

Bisaillon R, Moison C, Thiollier C, Krosl J, Bordeleau ME, Lehnertz B, Lavallée VP, MacRae T, Mayotte N, Labelle C, Boucher G, Spinella JF, Boivin I, D’Angelo G, Lavallée S, Marinier A, Lemieux S, Hébert J, Sauvageau G.
Genetic characterization of ABT-199 sensitivity in human AML.
Leukemia (2019), doi: 10.1038/s41375-019-0485-x.

Integrin-α3 Is a Functional Marker of Ex Vivo Expanded Human Long-Term Hematopoietic Stem Cells.

Tomellini E, Fares I, Lehnertz B, Chagraoui J, Mayotte N, MacRae T, Bordeleau MÈ, Corneau S, Bisaillon R, Sauvageau G.
Integrin-α3 Is a Functional Marker of Ex Vivo Expanded Human Long-Term Hematopoietic Stem Cells.
Cell Reports (2019), 28(4):1063-1073.

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.

Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G.
Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.
Cancer Cell (2019), 36(1):84-99.

Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin.

Lavallée VP, Chagraoui J, MacRae T, Marquis M, Bonnefoy A, Krosl J, Lemieux S, Marinier A, Pabst C, Rivard GÉ, Hébert J, Sauvageau G.
Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin.
Leukemia (2018), 32(6):1349-1357.

Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity.

Simon L, Lavallée VP, Bordeleau ME, Krosl J, Baccelli I, Boucher G, Lehnertz B, Chagraoui J, MacRae T, Ruel R, Chantigny Y, Lemieux S, Marinier A, Hébert J, Sauvageau G.
Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity.
Clinical cancer research (2017), 23(22):6969-6981.

H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations.

Lehnertz B, Zhang YW, Boivin I, Mayotte N, Tomellini E, Chagraoui J, Lavallée VP, Hébert J, Sauvageau G.
H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations.
Blood (2017), 130(20):2204-2214.

EPCR expression marks UM171-expanded CD34+ cord blood stem cells. Blood.

Fares I, Chagraoui J, Lehnertz B, MacRae T, Mayotte N, Tomellini E, Aubert L, Roux PP, Sauvageau G.
EPCR expression marks UM171-expanded CD34+ cord blood stem cells. 
Blood (2017), 129(25):3344-3351.

A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens. Blood Cancer J.

Baccelli I, Krosl J, Boucher G, Boivin I, Lavallée V-P, Hébert J, Lemieux S, Marinier A, Sauvageau G.
A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens.
Blood Cancer Journal (2017), 7(2):e529.

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo. Blood.

Pabst C, Bergeron A, Lavallée VP, Yeh J, Gendron P, Norddahl GL, Krosl J, Boivin I, Deneault E, Simard J, Imren S, Boucher G, Eppert K, Herold T, Bohlander SK, Humphries K, Lemieux S, Hébert J, Sauvageau G, Barabé F.
GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo.
Blood (2016), 127(16):2018-27.

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias

Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G.
The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.
Nature Genetics (2015), 47(9):1030-7.

E4F1 is a master regulator of CHK1-mediated functions.

Grote D, Moison C, Duhamel S, Chagraoui J, Girard S, Yang J, Mayotte N, Coulombe Y, Masson JY, Brown GW, Meloche S, Sauvageau G.
E4F1 is a master regulator of CHK1-mediated functions.
Cell Reports (2015), 11(2):210-9.

Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate.

Fortier S, MacRae T, Bilodeau M, Sargeant T, Sauvageau G.
Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate.
PNAS USA (2015), 112(7):2127-32.

Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.

Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G.
Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.
Science (2014), 345(6203):1509-12.

UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.

Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau G.
UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.
Blood (2014), 124(15):2362-9.

Identification of small molecules that support human leukemia stem cell activity ex vivo.

Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau G.
Identification of small molecules that support human leukemia stem cell activity ex vivo.
Nature Methods (2014), 11(4):436-42.

C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein.

Bisaillon R, Wilhelm BT, Krosl J, Sauvageau G.
C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein.
Blood (2011), 118(17):4682-9.

Roles for MSI2 and PROX1 in hematopoietic stem cell activity.

Hope KJ, Sauvageau G.
Roles for MSI2 and PROX1 in hematopoietic stem cell activity.
Current Opinion in Hematology (2011), 18(4):203-7.

An anticlastogenic function for the Polycomb Group gene Bmi1.

Chagraoui J, Hébert J, Girard S, Sauvageau G.
An anticlastogenic function for the Polycomb Group gene Bmi1.
PNAS USA (2011), 108(13):5284-9.

Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions.

Fortier S, Bilodeau M, Macrae T, Laverdure JP, Azcoitia V, Girard S, Chagraoui J, Ringuette N, Hébert J, Krosl J, Mayotte N, Sauvageau G.
Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions.
PLoS Genetics (2010), 6(12):e1001241.

Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer.

Sauvageau M, Sauvageau G.
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer.
Cell Stem Cell (2010), 7(3):299-313.

An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity.

Hope KJ, Cellot S, Ting SB, MacRae T, Mayotte N, Iscove NN, Sauvageau G.
An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity.
Cell Stem Cell (2010), 7(1):101-13.

A functional screen to identify novel effectors of hematopoietic stem cell activity.

Deneault E, Cellot S, Faubert A, Laverdure JP, Fréchette M, Chagraoui J, Mayotte N, Sauvageau M, Ting SB, Sauvageau G.
A functional screen to identify novel effectors of hematopoietic stem cell activity.
Cell (2009), 137(2):369-79.

Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia.

Sauvageau M, Miller M, Lemieux S, Lessard J, Hébert J, Sauvageau G.
Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia.
Blood (2008), 111(2):790-9.

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.

Lessard J, Sauvageau G.
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Nature (2003), 423(6937):255-60.

HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

Antonchuk J, Sauvageau G, Humphries RK.
HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.
Cell (2002), 109(1):39-45.

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b.

Kroon E, Krosl J, Thorsteinsdottir U, Baban S, Buchberg AM, Sauvageau G.
Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b.
EMBO Journal (1998), 17(13):3714-25.