Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.

Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G.
Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.
Science (2014), 345(6203):1509-12.

UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.

Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau G.
UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.
Blood (2014), 124(15):2362-9.

Identification of small molecules that support human leukemia stem cell activity ex vivo.

Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau G.
Identification of small molecules that support human leukemia stem cell activity ex vivo.
Nature Methods (2014), 11(4):436-42.