DDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition

/dans /par

Céline Moison, Rodrigo Mendoza-Sanchez, Deanne Gracias, Doris A Schuetz, Jean-François Spinella , Simon Girard , Bounkham Thavonekham , Jalila Chagraoui , Aurélie Durand , Simon Fortier , Tara MacRae , Eric Bonneil , Yannick Rose , Nadine Mayotte , Isabel Boivin , Pierre Thibault, Josée Hébert, Réjean Ruel , Anne Marinier, Guy Sauvageau.
DDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition.
EMBO Reports (2025).

Deciphering the effect of UM171 on human hematopoietic progenitor cell fate through clonal analysis

/dans /par

Patrick Coulombe, Elisa Tomellini, Jalila Chagraoui, Nadine Mayotte & Guy Sauvageau.
Deciphering the effect of UM171 on human hematopoietic progenitor cell fate through clonal analysis.
Nature Communications (2025).

Immunotherapeutic targeting of surfaceome heterogeneity in AML

/dans /par

Marie-Eve Bordeleau, Eric Audemard, Arnaud Metois, Louis Theret, Veronique Lisi, Azer Farah,
Jean-Francois Spinella, Jalila Chagraoui, Ossama Moujaber, Leo Aubert, Banafsheh Khakipoor, Laure Mallinger,
Isabel Boivin, Nadine Mayotte, Azadeh Hajmirza, Eric Bonneil, Francois Beliveau, Sybille Pfammatter,
Albert Feghaly, Genevieve Boucher, Patrick Gendron, Pierre Thibault,Frederic Barabe, Sebastien Lemieux,
Guillaume Richard-Carpentier, Josee Hebert, Vincent-Philippe Lavallee, Philippe P. Roux,
and Guy Sauvageau
Immunotherapeutic targeting of surfaceome heterogeneity in AML.
Cell Reports (2024).

SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia

/dans /par

Céline Moison, Deanne Gracias, Julie Schmitt, Simon Girard, Jean- François Spinella, Simon Fortier, Isabel Boivin, Rodrigo Mendoza- Sanchez, Bounkham Thavonekham, Tara MacRae, Nadine Mayotte, Eric Bonneil, Mark Wittman, James Carmichael, Réjean Ruel, Pierre Thibault, Josée Hébert, Anne Marinier, Guy Sauvageau.
SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia.
Science Advances (2024).

DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML

/dans , /par

Jean-François Spinella, Jalila Chagraoui, Céline Moison, Vincent P. Lavallée, Isabel Boivin, Deanne Gracias, Sylvie Lavallée, Guillaume Richard Carpentier , François Beliveau, Josée Hébert and Guy Sauvageau
DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML.
Leukemia (2024).

KBTBD4-mediated Reduction of MYC Is Critical For Hematopoietic Stem Cell Expansion Upon UM171 Treatment

/dans /par

Jalila Chagraoui, Simon Girard, Laure Mallinger, Nadine Mayotte, Maria Florencia Tellechea, Guy Sauvageau
KBTBD4-mediated Reduction of MYC Is Critical For Hematopoietic Stem Cell Expansion Upon UM171 Treatment.
Blood (2023).

Cohen et al. Blood Advances (2023)

/dans /par

Cohen S, Bambace N, Ahmad I, Roy J, Tang X, Zhang MJ, Burns LJ, Barabé F, Bernard L, Delisle JS, Kiss T, Lachance S, Roy DC, Veilleux O, Sauvageau G.
Improved Outcomes of UM171-Expanded Cord Blood Transplantation Compared with Other Graft Sources: Real-World Evidence.
Blood Advances (2023).

SPAT: Surface Protein Annotation Tool

/dans /par

Jean-François Spinella, Louis Theret, Léo Aubert, Eric Audemard, Geneviève Boucher, Sibylle Pfammatter, Eric Bonneil, Marie-Eve Bordeleau, Pierre Thibault, Josée Hébert, Philippe P. Roux, Guy Sauvageau
SPAT: Surface Protein Annotation Tool.
bioRxiv (2023).