SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia

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Céline Moison, Deanne Gracias, Julie Schmitt, Simon Girard, Jean- François Spinella, Simon Fortier, Isabel Boivin, Rodrigo Mendoza- Sanchez, Bounkham Thavonekham, Tara MacRae, Nadine Mayotte, Eric Bonneil, Mark Wittman, James Carmichael, Réjean Ruel, Pierre Thibault, Josée Hébert, Anne Marinier, Guy Sauvageau.
SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia.
Science Advances (2024).

KBTBD4-mediated Reduction of MYC Is Critical For Hematopoietic Stem Cell Expansion Upon UM171 Treatment

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Jalila Chagraoui, Simon Girard, Laure Mallinger, Nadine Mayotte, Maria Florencia Tellechea, Guy Sauvageau
KBTBD4-mediated Reduction of MYC Is Critical For Hematopoietic Stem Cell Expansion Upon UM171 Treatment.
Blood (2023).

DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML

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Jean-François Spinella, Jalila Chagraoui, Céline Moison, Vincent P. Lavallée, Isabel Boivin, Deanne Gracias, Sylvie Lavallée, Guillaume Richard Carpentier , François Beliveau, Josée Hébert and Guy Sauvageau
DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML.
Leukemia (2023).

Cohen et al. Blood Advances (2023)

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Cohen S, Bambace N, Ahmad I, Roy J, Tang X, Zhang MJ, Burns LJ, Barabé F, Bernard L, Delisle JS, Kiss T, Lachance S, Roy DC, Veilleux O, Sauvageau G.
Improved Outcomes of UM171-Expanded Cord Blood Transplantation Compared with Other Graft Sources: Real-World Evidence.
Blood Advances (2023).