Self-renewal is the key cellular process that underlies hematopoietic stem cells (HSC) expansion. It is therefore critical to understand its basis for the development of new HSC-expansion tools. Our laboratory current research projects aim to map and dissect HSC self-renewal networks, using 3 complementary approaches.
The low cell dose of cord blood (CB) results in delay or absence of engraftment, increasing early mortality. Therefore only 5% of stored CBs are suitable for adults. The ideal graft source would be a CB, simultaneously expanded for HSPCs, T cells and megakaryocyte progenitors. Expansion of anti-leukemia natural killer (NK) cells would also represent an important added benefit.
There are several unmet needs in AML diagnosis and therapy. Accurate prognostic tools to better orient patients to receive the optimal therapy are currently unavailable for more than half of AML patients. There is also an urgent need to develop novel and effective therapeutic strategies for high-risk or refractory/relapsing patients and for patients unfit to receive intensive therapy.
In this project we use a newly generated collection of segmental haploid chromosomal deletions which covers, in 1300 different clones, over 25% of the genome of the mouse ES cells. Using a BAC complementation strategy adapted for large scale studies, we have recently identified several regions which are haploinsufficient for ESC differentiation . This new resource and method will help elucidate novel determinants of stem cell fate.
November 22, 2017
lab currently accepting applications for exceptional
PhD students. If you are passionate about research
and interested in joining our team, please submit
your application toTara MacRae.
2017 IRIC Next Generation awards
The 2017 IRIC Next Generation Awards program offers students an unique opportunity to receive an undergraduate research award and to conduct an
internship at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal during Summer 2017.
Application deadline Friday, February 3, 2017, 5 PM
2017 IRIC Student Recruitment Event
The 2017 IRIC Student Recruitment Event offers students interested in pursuing graduate studies in the field of cancer research a unique opportunity to participate in an international student
recruitment event at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal, from June 15 to June 18, 2017.
Application deadline Monday, March 13, 2017, 5 PM
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