Research Projects


HSC Self-Renewal Networks



Self-renewal is the key cellular process that underlies hematopoietic stem cell (HSC) expansion. It is therefore critical to understand its basis for the development of new HSC-expansion tools. Our laboratory's current research projects aim to map and dissect HSC self-renewal networks, using 3 complementary approaches.


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An Ideal Cord Blood Graft



The low cell dose of cord blood (CB) results in delay or absence of engraftment, increasing early mortality. Therefore only 5% of stored CBs are suitable for adults. The ideal graft source would be a CB, simultaneously expanded for HSPCs, T cells and megakaryocyte progenitors. Expansion of anti-leukemia natural killer (NK) cells would also represent an important added benefit.

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Acute Myeloid Leukemia



There are several unmet needs in AML diagnosis and therapy. Accurate prognostic tools to better orient patients in receiving optimal therapy are currently unavailable for more than half of AML patients. There is also an urgent need to develop novel and effective therapeutic strategies for high-risk or refractory/relapsing patients and for patients unfit to receive intensive therapy.

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Stem Cell Determinants



In this project we use a novel collection of segmental haploid chromosomal deletions which covers over 25% of the genome of the mouse ES cells, in 1300 different clones. Using a BAC complementation strategy adapted for large scale studies, we have recently identified several regions which are haploinsufficient for ESC differentiation. This new resource and method will help elucidate novel determinants of stem cell fate.

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News



May, 2017
 
The Sauvageau lab currently accepting applications for exceptional PhD students. If you are passionate about research and interested in joining our team, please submit your application to Marie-Eve Bordeleau.

IRIC Next Generation awards

The IRIC Next Generation Awards program offers students an unique opportunity to receive an undergraduate research award and to conduct an internship at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal during the summer.

Please try next year! Application deadline is in February.

IRIC Student Recruitment Event

The IRIC Student Recruitment Event offers students interested in pursuing graduate studies in the field of cancer research a unique opportunity to participate in an international student recruitment event in June at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal.

Please try next year!


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