1. Optimizing HSC production
Our lab recently identified the small molecule UM729 and its optimized version UM171, which enhances self-renewal (expansion) of human HSCs3-4. UM171 should generate extensive clinical benefits such as:
To further improve HSC production, newly discovered molecules which synergize with UM171 to expand human HSCs will be optimized. If successful, this will lead to faster neutrophil recovery after transplantation. It will also reduce the volume and duration of our cultures, two major issues for generation of clinically-relevant culture protocols.
- abrogating the prolonged aplasia and consequent infections
- allowing the use of smaller better-matched CB
- decreasing the risk of transplant mortality.