HSC Self-Renewal Networks

Mapping and dissecting human HSC self-renewal networks

Towards an ideal cord blood graft

Chemo-genomic tools to produce the ideal cord blood graft

Acute Myeloid Leukemia

Understanding AML with chemo-genomics

Genome Wide Annotation of Stem Cell Determinants

Interrogation of mammalian stem cell fate regulators


  • HSC Self-Renewal Networks


  • Towards an ideal cord blood graft


  • Acute Myeloid Leukemia


  • Genome Wide Annotation of Stem Cell Determinants


Sauvageau Lab


Based in Montréal, Canada, the Sauvageau Lab is part of the Institute for Research in Immunology and Cancer (IRIC), at Université de Montréal.

Our research program aims to decipher the basic mechanisms that regulate the activity of normal and leukemia stem cells with the ultimate goal of identifying regulatory networks that govern specification and self-renewal of these cells.

Our approach exploits novel methods for functional genomics and chemo-genomics to identify uncharacterized regulators of stem cell activity.


Recent Publications

EPCR expression marks UM171-expanded CD34+ cord blood stem cells.
Fares I, Chagraoui J, Lehnertz B et al.
In this article, we identify EPCR as a highly reliable surface marker for expanded human HSCs, independently of the culture conditions or duration. We also demonstrate that EPCR defines a cell population with sustained short- and long-term repopulating activity and show that the transcriptional profile of expanded EPCR+ cells significantly matches that of freshly sorted HSCs. Finally, we provide evidence for a crucial role for EPCR in human HSC self-renewal.
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New website

New website for the Leucegene project

The new Leucegene website is now online. This project aims to increase the survival rate of patients with acute myeloid leukemia by helping to determine treatment based on the genetic makeup of their leukemia cells. It is headed by Drs Guy Sauvageau (Project Leader), Josée Hébert (Co-Project Leader), Anne Marinier (Head Chemist) and Sébastien Lemieux (Head of Bioinformatics). It involves researchers from IRIC, HMR, Université Laval and McGill University.

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Recent news


June, 2017
Vincent-Philippe Lavallée, a PhD student in the Sauvageau lab, received an important grant from the Vanier Canada Graduate Scholarship (Vanier CGS) program. This 3-year scholarship from the Canadian Institutes of Health Research (CIHR), rewards students that distinguish themselves for their leadership and academic excellence.

April, 2017 - ExCellThera wins the first prize at the HealthKick Challenge in Toronto
ExCellThera, a clinical-stage spin-off company based on the Sauvageau lab's work on stem cell expansion, won the $20,000 first prize in the Pharma and Biotech category at the HealthKick Challenge, which took place in Toronto, Ontario, on April 5th.

IRIC - Université de Montréal


"Despite considerable efforts and spectacular scientific advances to fight this disease, effective treatments are lacking for most types of cancer. An ultra-modern research and training centre located in the heart of Université de Montréal, the Institute for Research in Immunology and Cancer (IRIC) was created in 2003 to shed light on the mechanisms of cancer and discover new, more effective therapies to counter this plague." (IRIC, 2014)

To learn more about the Institute, visit www.iric.ca.

News



May, 2017
 
The Sauvageau lab currently accepting applications for exceptional PhD students. If you are passionate about research and interested in joining our team, please submit your application to Marie-Eve Bordeleau.

IRIC Next Generation awards

The IRIC Next Generation Awards program offers students an unique opportunity to receive an undergraduate research award and to conduct an internship at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal during the summer.

Please try next year! Application deadline is in February.

IRIC Student Recruitment Event

The IRIC Student Recruitment Event offers students interested in pursuing graduate studies in the field of cancer research a unique opportunity to participate in an international student recruitment event in June at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal.

Please try next year!


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